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Projects / Programmes
Influencing chondrocyte differentiation phenotype 'in vitro' by 3D scaffolds
Research activity
| Code | Science | Field | Subfield |
|---|---|---|---|
| 7.00.00 | Interdisciplinary research |
| Code | Science | Field |
|---|---|---|
| T490 | Technological sciences | Biotechnology |
Keywords
chondrocytes, hydrogel, cell phenotype, differentiation, autologous chondrocyte implantation
Evaluation
(metodology)
Citations
Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
Organisations (3) , Researchers (13)
0311 Blood Transfusion Centre of Slovenia
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 01302 | Biotechnology | Researcher | 2005 - 2008 | 386 | |
| 2. | 10038 | Biotechnology | Researcher | 2005 - 2008 | 296 |
0312 University Medical Centre Ljubljana
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 21500 | Neurobiology | Researcher | 2005 - 2008 | 269 | |
| 2. | 14343 | Neurobiology | Researcher | 2005 - 2008 | 86 |
7421 EDUCELL cell therapy service Ltd. Ljubljana
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 15627 | Biochemistry and molecular biology | Head | 2005 - 2008 | 91 | |
| 2. | 16341 | Microbiology and immunology | Researcher | 2005 - 2006 | 16 | |
| 3. | 25484 | Biotechnology | Young researcher | 2005 - 2008 | 56 | |
| 4. | 28888 | Pharmacy | Technical associate | 2007 - 2008 | 0 | |
| 5. | 19120 | Biotechnology | Researcher | 2007 - 2008 | 50 | |
| 6. | 16002 | Biotechnology | Researcher | 2005 - 2008 | 347 | |
| 7. | 21228 | Microbiology and immunology | Researcher | 2005 - 2006 | 166 | |
| 8. | 28889 | Technical associate | 2007 - 2008 | 0 | ||
| 9. | 26275 | Biotechnology | Technical associate | 2007 - 2008 | 8 |
Abstract
We are confronting two problems at autologous chondrocyte implantation: chondrocyte dedifferentiation in monolayer culture and invasiveness of surgical procedure. Our intention is to make a tissue-engineered construct of three-dimensional gel scaffold that promotes chondrocyte cell phenotype and enables less invasive operation procedure. To monitor the differentiation state of chondrocytes a method for quantitative evaluation of gene expression by real-time PCR will be introduced.