Projects / Programmes source: ARIS

Inflammatory markers and 31P NMR spectroscopical changes in erythrocytes in critically ill children

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Research activity

Code Science Field Subfield
3.05.00  Medical sciences  Human reproduction   

Code Science Field
B007  Biomedical sciences  Medicine (human and vertebrates) 
B590  Biomedical sciences  Anaesthesiology, intensive care 
B660  Biomedical sciences  Pediatrics 
Keywords
Neonatal, paediatric intensive care - hospital infection - diagnosis -procalcitonin - interleukin-6 - interleukin-8 - C-reactive protein - lipopolysaccharide binding protein - PRISM score - febrile neutropenia
Evaluation (metodology)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Organisations (2) , Researchers (13)
0104  National Institute of Chemistry
no. Code Name and surname Research area Role Period No. of publications
1.  05454  Aleksander Gačeša    Researcher  2002 - 2004  12 
2.  10082  PhD Janez Plavec  Chemistry  Researcher  2002 - 2004  1,339 
0312  University Medical Centre Ljubljana
no. Code Name and surname Research area Role Period No. of publications
1.  05273  PhD Janez Babnik  Human reproduction  Researcher  2002 - 2004  181 
2.  02148  PhD Metka Derganc  Human reproduction  Head  2002 - 2004  457 
3.  15706  PhD Tanja Gmeiner  Pharmacy  Researcher  2002 - 2004  147 
4.  06756  PhD Štefan Grosek  Human reproduction  Researcher  2002 - 2004  658 
5.  01900  PhD Sergej Hojker  Human reproduction  Researcher  2002 - 2004  315 
6.  12445  MSc Gorazd Kalan  Human reproduction  Researcher  2002 - 2004  121 
7.  19257  PhD Lidija Kitanovski  Oncology  Researcher  2002 - 2004  166 
8.  10691  PhD Joško Osredkar  Human reproduction  Researcher  2002 - 2004  1,337 
9.  02179  PhD Janez Primožič  Human reproduction  Researcher  2002 - 2004  274 
10.  15443  MSc Alenka Sešek Briški  Metabolic and hormonal disorders  Researcher  2002 - 2004  104 
11.  07793  Ivan Vidmar  Human reproduction  Researcher  2002 - 2004  251 
Abstract
Severe infection is the most common cause of morbidity and mortality in the paediatric intensive care unit (PICU). Diagnosis of severe infection in the critically ill newborns and children is often difficult because of non-specific clinical and routinely used laboratory markers of infection. Critically ill newborns and children with both medical and surgical diseases suspected of having severe hospital infection will be included in the study. Dynamics of blood concentration of procalcitonin (PCT), IL-6 and IL-8 will be compared with leukocyte count and differential and concentrations of C-reactive protein (CRP). Concentration of inflammatory markers will be correlated with severity of disease (PRISM-paediatric risk of mortality score) and type of isolated microorganisms. 31P nuclear magnetic resonance spectroscopy will be used to study phosphate metabolites in red blood cells in severe infection and other shock states. The value of PCT and IL-6 determination in comparison with CRP will be studied also in children with oncological diseases with febrile neutropenia
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