The significance of our research for science in general is multifaceted, the subject matter of the program is mostly fundamental biophysics and physics of soft matter in general, with ramificatious for medical science in general. The detailed understanding of the biomechanics of the cell wall is one of the keys to the understanding of the workings of the cell, as was recently clearly seen in the analysis of the formation of the echinocyte where the cytoskeleton plays a fundamental role. It is to be expected that a detailed study of lyposomes and simple cell models will enrich our understanding of the lipid membrane and its role in cellular process underlying different cellular pathologies. We can expect that understanding and the concomitant control of diferent physiological processes in the cell will contribute significantly to the further development of the medical sciences. The physics of colloids is still characterized by a broad gap between experiments and theoretical models. Experimental studies of colloids have grown substantially in recent times mostly due their easy accessibility and/or low cost. The explanations of the observed phenomena are nevertheless mostly still lacking. In the light of the relevance of the physics of colloids for the understanding of various biological processes and the development of complex new materials the theoretical analysis is higly desirable. The mesophases of nucleosome core particles are a fundamental step in the elucidation and reconstruction of the eucaryotic chromosomes and the packing of DNA within them. Available experiments on reconstituted chromosomes give sufficient information, so that their detailed theoretical analysis is more than sensible. We are in a unique position since we have a broad enough expertise to attempt such an analysis