Human papillomavirus (HPV) is an important etiological factor in oropharyngeal squamous cell carcinoma (SCC). Compared to HPV-negative tumors, HPV-positive oropharyngeal SCC has shown a better response to nonsurgical treatments. In this study, we determined the dose-modifying factors for HPV-positive tumors with single-dose irradiation, with or without low radiosensitizing doses of cisplatin. In vitro, we determined an increased radiosensitivity of HPV-positive SCC, which might be a consequence of HPV-induced changes in the cell cycle regulation and DNA damage response, leading to increased cell death. Additionally, compared to HPV-negative tumors, 30% higher radiosensitivity of HPV-positive tumors was determined by tumor growth delay monitoring in immunodeficient mice in vivo. Concurrent cisplatin treatment had an additive effect in both HPV-negative and HPV-positive tumors, resulting in 20% better response in HPV-positive tumors than in HPV-negative tumors.
COBISS.SI-ID: 2923643
Lecture given at the 8th CETO conference (Conference on Experimental and Translational Oncology) which was conducted between April 19-21, 2017 in Portorož Slovenia. In their lecture, authors synthetized recent epidemiological, preclinical and clinical data on the role of HPV infection in development and treatment of squamous cell carcinoma of the oropharynx, and presented directions for development of clinical research in this area in the future. Relevant data for Slovenia was also presented.
COBISS.SI-ID: 2643067
In the Ph-D. Thesis, the hypotheses and work objectives under consideration were identical to those in the J3-7460 project. The same holds true for carrying out the tasks and for presented results.
COBISS.SI-ID: 297155584