1.

Activation of Toll like receptors with cross-linked agonists

In the research we examined the effect of cross-linked flagellin and oligonucletides to peptides forming coiled-coils on activation of TLR5 and TLR9 receptor. We showed that agonists cross-linked to CC-peptides preserved the characteristics of agonists and that CC-peptides can be used as cross-linkers for agonists.

D.10 Educational activities

COBISS.SI-ID: 1537134531

2.

Vpliv flagelina na aktivacijo inflamasoma

We demonstrated that flagellin activates not only TLR5 but also inflammasome by binding to the receptor NAIP5/NLRC4. We showed that the C-terminal part of flagellin is critical for activation of inflammasome. This work confirmed that flagellin could be used as activator of membrane and cytosolic receptors of innate immunity.

D.10 Educational activities

COBISS.SI-ID: 4067663

3.

Lecture: TLR9 - synthetic agonists - species and sequence specificity

The lecture introduces latest findings on mechanisms of activation of TLR9 with synthetic agonists.

B.04 Guest lecture

COBISS.SI-ID: 6076954