1.

Comparison of pigment cell ultrastructure and organisation in the dermis of marble trout and brown trout, and first description of erythrophore ultrastructure in salmonids

The paper presents the first description of the ultrastructure of pigment cells in the two species of trout, which differ significantly according to the color pattern, which is an important character of their distinction. The complexity of the formation of color pattern is explained by the function and development of pigment cells, where the ultrastructure of erythrofore plays a decisive role.

COBISS.SI-ID: 3615624

2.

Potential of genotyping-by-sequencing for genomic selection in livestock populations

The article represents potential use of genotyping by sequencing for the purpose of genomic selection. This method allows coverage of the entire genome and correlates both polymorphisms detected by sequencing with phenotypic traits that are important for production traits.

COBISS.SI-ID: 3522696

3.

Lessons from hepatocyte-specific cyp51 knockout mice

We demonstrate unequivocally that defective cholesterol synthesis is an independent determinant of liver inflammation and fibrosis. We prepared a mouse hepatocyte-specific knockout (LKO) of lanosterol 14 a -demethylase (CYP51) from the part of cholesterol synthesis that is already committed to cholesterol. LKO mice developed hepatomegaly with oval cell proliferation, fibrosis and inflammation, but without steatosis. Our data place defective cholesterol synthesis as a focus of sex-dependent liver pathologies.

COBISS.SI-ID: 31858137

4.

Identification of natural ROR[gamma] ligands that regulate the development of lymphoid cells

Mice deficient in the nuclear hormone receptor ROR[gamma]t have defective development of thymocytes, lymphoid organs, Th17 cells, and type 3 innate lymphoid cells. ROR[gamma]t binds to oxysterols derived from cholesterol catabolism, but it is not clear whether these are its natural ligands. Here, we show that sterol lipids are necessary and sufficient to drive ROR[gamma]t-dependent transcription. Our data suggest that CBIs play a role in lymphocyte development potentially through regulation of ROR[gamma].

COBISS.SI-ID: 3506824

5.

Population genetic SNP analysis of marble and brown trout in a hybridization zone of the Adriatic watershed in Slovenia

The article shows the effects of hybridization of two populations of trout , which co-habituate in the Adriatic watershed in Slovenia and suggests a scenario of population events and selection pressures on populations in the course of their history.

COBISS.SI-ID: 3517576