1.

Low-dose fluvastatin and valsartan rejuvenate the arterial wall through telomerase activity increase in the middle-aged men

In this study it was found that a low-dose combination of fluvastatin and valsartan substantially increased telomerase activity, which significantly correlated with an improvement of endothelial function and a decrease of inflammation/oxidative stress. These findings could lead to a new innovative approach to arterial rejuvenation.

COBISS.SI-ID: 2061947

2.

Platelet reactivity in comatose survivors of cardiac arrest undergoing percutaneous coronary intervention and hypothermia

Post-resuscitation syndrome with onhoing hypothermia is associated with decreased platelet reactivty. Clopidogral loading does not significantly affect platelet function during the first 48 hours. This is contrast with eptifibatide which produces profound platelet inhibition, and may be used to bridge insufficient inhibition by clopidogrel.

COBISS.SI-ID: 1551020

3.

Do blood constituents in varicose veins differ from the systemic blood constituents?

Some inflammatory markers and indicators of endothelial dysfunction are increased in varicose vein blood. This is most probably the consequence of deteriorated blood flow in dilated nad tortuous superficial veins, and increased venous pressure. Damage to the venous wall, which causes a chronic inflammatory response, together with the procoagulant properties of local blood may promote further progression of the disease and thrombotic complications.

COBISS.SI-ID: 2649772

4.

Dabigatran concentration

Routine laboratory monitoring is currenty notrecommended in patients receiving dabigatran despite its considerable variation in plasma concentration. Dabigatran dose selection according to the guidelines resulted in appropriate trough concentrations with acceptable repeatability. High trough concentrations may predispose patients to the risk of minor bleeding.

COBISS.SI-ID: 2317740

5.

Time course and the recanalization rate of superficial vein thrombosis treated with low-molecular-weight heparin

The aim of this study was to follow the thrombus progression and regression in superficial veins of lower limbs in patient with superficial vein thrombosis (SVT) treated with low-molecular-weight heparin. The reduction in the lenght of thrombosis as well as thrombus diameter was significantly greater in females. At the end of the observation period, the lenght of thrombus in the distal part was more reducec than in the proximal segments. It seems that the dosage of anticoabulant drug does not have a significant impact on thrombus resolution.

COBISS.SI-ID: 2738860