Post-resuscitation syndrome with ongoing hypothermia is associated with decreased platelet reactivity. Clopidogrel loading does not significantly affect platelet function during the first 48 hours. This is in contrast with eptifibatide which produces profound platelet inhibition, and may be used to bridge insufficient inhibition by clopidogrel.
COBISS.SI-ID: 1551020
Plasmin is a novel thrombolytic agent that acts locally inside the thrombus and causes less distant bleeding than recombinant tissue-type plasminogen activator (rtPA). Our research showed that plasmin was as effective as rtPA in ex-vivo thrombolysis of blood clots retrieved from intracranial arteries that had caused ischaemic stroke.
COBISS.SI-ID: 28967385
Both interval and continuous exercise training modalities were safe. Interval training seems more efficacious in improving exercise capacity, vascular function, NT-proBNP and fibrinogen levels, while continuous training seems more efficacious in improving cardiac autonomic function and QoL.
COBISS.SI-ID: 7992339
In women with chest pain, 64-slice multidetector CCTA is at least as sensitive and specific as in men. Our findings suggest that CCTA is a promising diagnostic tool for timely detection and/or exclusion of CAD in symptomatic intermediate-risk female populations.
COBISS.SI-ID: 2076844
Heart failure is characterised by activation of haemostasis. We sought to explore the prognostic impact of deranged haemostasis in chronic heart failure. Our findings suggest that elevated tPA antigen levels are an independent prognostic predictor in patients with chronic stable heart failure.
COBISS.SI-ID: 516307993
Compared to standard treatment, intensive insulin treatment of critically ill patients increases forearm flow. Flow increase was weakly related to the insulin dose, though not to blood glucose concentration.
COBISS.SI-ID: 26457817
A study on the effect of a combination of low-dose fluvastatin and valsartan on inflammatory and oxidative stress markers in patients with type 1 diabetes mellitus was performed. After 30 days of treatment with a combination of low doses of these drugs, there was a significant reduction in inflammation and oxidative stress in patients with type 1 diabetes mellitus. These results correlated with the improvement of arterial function parameters.
COBISS.SI-ID: 33170649
In the animal model, the low doses of fluvastatin in valsartan have been studied compared to high doses of the same drugs. The study revealed that the low doses were more effective in improving arterial and cardiac function.
COBISS.SI-ID: 4146604
We found that subtherapeutic low-dose fluvastatin (10mg daily; 30 days) considerably improves and reverses early functional and morphological arterial wall impairments that are present in apparently healthy, middle-aged males. It might be supposed that such a new and original approach could be valuable in cardiovascular prevention.
COBISS.SI-ID: 28582873
Our study showed that systemic endothelial function is not impaired in migraine patients without comorbidities, neither in those with or without aura. Considering these findings, the investigation of cerebral endothelial function would be useful in a further investigation of the role of endothelial (dys)function in migraine pathophysiology.
COBISS.SI-ID: 28351705