The aim of this research was to develop a novel medical tampon for alternative gynaecological treatment using chitosan nanoparticles as an antimicrobial agent or as a drug delivery system. For this viscose tampon band was used and functionalized with chitosan and trimethyl chitosan nanoparticles. A comprehensive study of interactions between chitosan and cellulose as well as characterization of prepared materials was done. Evaluation of antimicrobial properties was performed using two different techniques, both revealing a high inhibition of the tested microorganism. In addition, Lactobacillus susceptibility testing has shown that chitosan coated fibres do not have any negative influence on the resident microbiota. Assessment of in vitro cytotoxicity demonstrated that samples do not cause a cytotoxic effect in direct contact. Additionally, model drug was incorporated into chitosan nanoparticles and subsequently attached onto fibres in order to create modern, vaginal drug delivery systems. Antimicrobial medical textiles investigated in the scope of this research show the potential for their exploitation in gynaecological field as preventive or curative treatment without triggering any adverse effects for the user.
B.04 Guest lecture
COBISS.SI-ID: 19000854Textiles may contain different types of microorganisms, thus posing a potential risk for the health of patients and staff in health facilities/institutes. Conventional procedures, such as thermal, chemical, or by a combination of both procedures are being used less prevalently due to their large consumption of energy, water, and high-concentrations of chemicals. Therefore intensive research and development are being carried on new textile care technologies and processes. One of them, nowadays widely used in, is low temperature ozone laundering procedure. Research has focused on the washing and disinfection effectiveness of domestic ozone laundering. Domestic washing machine, commercial ozone unit, IEC detergent, textile bioindicators with different micro-organisms and ballast cotton textiles was used. After ozone laundering phase, whit different washing baths and at different temperatures, the evaluations of washing and disinfection effects were performed. The results from this performed study show that ozone laundering procedure reduce concentration of microorganisms, but it is very dependent from temperature and pH of washing bath. inadequate qualities of laundering wastewaters greatly burden the environment. We believe, that modification of laundering conditions will be reflected in higher washing as disinfection effects.
B.04 Guest lecture
COBISS.SI-ID: 18750486Multidimensionally photopatterned substrates on the basis of monosaccharide derivatives, their oligomers and their polymers and a method of production there-of solve above referenced technical problem by use of silylated sugar/polysaccharide derivatives, further 3-D structuring, and use of enzymes to obtain positive and negative resists is presented.
F.09 Development of a new technological process or technology
COBISS.SI-ID: 18559766Polysaccharides (PS) as materials have a huge potential to be applied in advanced biomedical applications. For many of their functions surface properties and the interaction at the materials` interfaces are crucial. By having a detailed understanding of wetting, adsorption/desorption, adhesion and morphology, PS materials with desired surface properties can be created. Well defined thin films of PS are one platform that can be used to elucidate these surface phenomena[1]. Knowledge obtained from basic studies on thin films can then be transferred to the development of functional materials. Characterization of their defined composition is performed with modern surface analytical methods such as a quartz-crystal microbalance, surface plasmon resonance, and X-ray photoelectron spectroscopy. As an example, these films can further be surface structured and serve as a basis for functional layers in optical sensors for the detection of DNA and proteins[2]. The biological efficacy of many charged polysaccharides can also be exploited in the coating of metal (nano-) particles on modern wound dressings, having antimicrobial properties. Electrospinning of PS with incorporated functional ingredients presents another possibility to develop functional wound dressings that are super-absorbing and analgesic[3]. Different PS spinning formulations and PS wound dressings were studied with respect to surface properties, biocompatibility, bioactivity, wettability, and morphology. In this presentation an overview on the current achievements in the fields of polysaccharide materials research will be given.
B.04 Guest lecture
COBISS.SI-ID: 18808086The invention belongs to the field of processes for preparing nanostructures, more precisely to the field of processes for preparing homogeneous superparamagnetic hollow spherical nanostructures with a porous shell based on iron oxide. The technical problem, which is solved by the present invention, is the design of a process for preparing hollow magnetic spherical nanostructures based on coating of solid silicon dioxide cores with magnetic nanoparticles of iron oxide in a spinel crystal structure and formation of hollow spheres using appropriate buffer solutions, which will be useful in a broad field of biomedicine and environmental protection, and will enable responsiveness and manoeuvrability of the entire hollow nanostructure using external magnetic field, as well as local release of an active substance due to the porous shell.
F.06 Development of a new product
COBISS.SI-ID: 18990358