1.

Continuous production of bacteriophages

In the chapter of the monograph different bioreactor systems for continuous production of bacteriophages, analysis of population dynamics bacteria/bacteriophages, the influence of selection pressure on mutation and stability of bacteriophages as well as the ways of isolation of bacteriophages are described.

F.02 Acquisition of new scientific knowledge

COBISS.SI-ID: 4505720

2.

Chromatographic monoliths

In the lecture the history of the development of chromatographic monoliths, their geometry, structural properties which differ them from particle supports and fields of their application is described.

B.04 Guest lecture

COBISS.SI-ID: 1536630979

3.

The increase of oxygen concentration in the bioprocess medium as a measure of the completion of the production of bacteriophages with bacteria of the genus Campylobacter

The criteria for the determination of the moment in bioprocess of multiplication of bacteriophages specific to the genus Camphylobacter at the maximal concentration of released bacteriophages are presented. The criterion are determined on basis of measurement of dissolved oxygen concentration which is unusual since the bacteria belong to the genus Camphylobacter microaerophili. The process must be completed with regard to the proposed criterion when the concentration of oxygen increases at least at a rate of 0,05%/min when the concentration at least 20% of the initial value is achieved.

F.09 Development of a new technological process or technology

COBISS.SI-ID: 1559693

4.

Quality of water quality data - consistency of the results of chemical analyses and sources of uncertainty

This research is focused on the uncertainty sources and limitations in determining a total ionic composition of natural water with ion chromatography. The chapter is organized into sections corresponding to the steps performed during an analytical process. Each section is focused on a particular case study with the objective of recognizing and evaluating uncertainty contributions with a bottom-up approach. Methodology necessary for these evaluations is described and applied to give answers on the importance of particular contributions. This chapter tends to develop guidance and strategies applicable to new complex cases.

F.02 Acquisition of new scientific knowledge

COBISS.SI-ID: 1536532163

5.

Bioreactor system for the continuous cultivation of bacteriophages

The subject of the invention is a bioreactor system for the continuous cultivation of bacteriophages, which is composed of interconnected mixer and a tubular reactor through which the fluid flows constantly. In a stirred reactor bacterial cells are cultured. The constant flow brings the nutrients to the cells which are then transferred into a tubular reactor. During transfer, the cells are infected with the purified phages. In the tubular reactor multiplication of bacteriophages takes place without additional nutrients or active mixing.