FePt nanoparticles were shown to be very promising candidate for use as T2 contrast agents in MRI. Biocompatible zwitterionic catechol ligand was used on the FePt nanoparticles for the first time. Formation of “multi-core” FePt nanoparticles leads to an increase in the magnetization and relaxivity values, which indicate the superiority of the “multi-core” FePt nanoparticles over the “single-core” ones.
COBISS.SI-ID: 29092647
Water suspension of hybrid FePt/SiO2/Au nanoparticles were irradiated with a low-energy laser and an increase in the temperature confirmed the photothermal effect. Furthermore, it was shown that the same suspension can be magnetically manipulated and retained at a targeted location under realistic dynamic conditions.
COBISS.SI-ID: 28708903
Simultaneous antibacterial and anticoagulant surfaces have been prepared by immobilization of engi-neered gold nanoparticles onto different kinds of surfaces. The gold nanoparticle core is surrounded by a hemocompatible, anticoagulant polysaccharide, 6-O chitosan sulfate, which serves as reduction and stabilizing agent for the generation of gold nanoparticles in a microwave mediated reaction. The par-ticle suspension shows anticoagulant activity, which is investigated by aPTT and PT testing on citrated blood samples of three patients suffering from congenital or acquired bleeding disorders. The amount of nanoparticles deposited on the surfaces is quantified by a quartz crystal microbalance with dissipation unit. All gold containing surfaces exhibit excellent antimicrobial properties against the chosen model organism, Escherichia coli MG 1655 [R1-16]. Moreover, blood plasma coagulation times of the surfaces are increased after deposition of the engineered nanoparticles as demonstrated by QCM-D.
COBISS.SI-ID: 512439352