Background: Preoperative distinction between benign and malignant follicular or Hürthle cell neoplasms based on cytologic examination of a fine-needle aspiration biopsy specimen is not possible. The aim of this study was to establish the cut-off value of the preoperative serum Tg concentration as a predictive factor of malignant disease in patients with a follicular or Hürthle cell neoplasm. Methods: In total, 667 patients (555 females, 112 males, age range 9-86 years, median age 52 years) with follicular or Hürthle cell neoplasm were surgically treated at out Institute from 1988 to 2009. Results: Altogether, 634 patients (555 females, 112 males, age range 9-86 years, median age 53 years) had negative Tg-autoantibodies and were included in our study. The median tumor size was 3 cm (range 0.4-12 cm). The histopathological diagnoses were carcinoma, adenoma and benign goiter in 189 (30%), 253 (40%) and 192 (30%) patients, respectivelyThe independent predictors of malignancy as shown by multivariate logistic regression were: tumor larger than 4 cm (OR 1.73 P= 0.011), solitary tumor (OR 1.52, P=0.037), and Tg concentration of more than 499 ng/mL (OR 1.85, P=0.003). Conclusion: A total thyroidectomy should be considered in patients with follicular or Hürthle cell neoplasm in the case of solitary tumor larger than 4 cm and preoperative Tg concentration higher than 499 ng/mL, as the possibility of malignancy is significant.
F.22 Improvement to existing health/diagnostic methods/procedures
COBISS.SI-ID: 1872251Surgery is a modern and comprehensive textbook on surgery for medical students in Slovenian language. Chapter Thyroid was written by Professor Nikola Bešić very systematically. He presented the embryology and anatomy, epidemiology, classical and modern methods of diagnostics and treatment of pathological changes of the thyroid gland. A major emphasis was on multidisciplinary and interdisciplinary approach in the treatment of thyroid cancer.
D.10 Educational activities
COBISS.SI-ID: 1772923In a prospective randomized study we included 120 patients who had surgical procedure for breast cancer. In the first group of subjects were those who had axillary lymphadenectomy. The second group of subjects consisted of patients who had immediate reconstruction with tissue extender. Elastomeric pump with a local anesthetic is effective, safe, for a patient and staff friendly method of relieving postoperative pain. It is effective after axillary lymphadenectomy and after immediate reconstruction with tissue extender. The use of continuous infusion of local anesthetic in a surgical wound reduces postoperative pain, reduces the consumption of opioids, postoperative nausea and sedation. Chronic pain (three months after surgery) is less frequent after the infusion of local anesthetic than after standard intravenous analgesia with opioids.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 1704827Cytogenetic changes and immunophenotypes in response to arsenic trioxide were studied in multiple myeloma cells. Altogether 34 samples of multiple myeloma from bone marrow were analysed by flow cytometry with annexin. We found that, in contrast to 2 μM, 5 μM concentration of arsenic trioxide selectively cause apoptosis of multiple myeloma cells. However, there has been no apoptosis in the other hematopoietic cells.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 274098432Guidelines for the management of patients with malignant lymphomas include new knowledge that will lead to better treatment of patients with this disease. These guidelines represent a joint effort to harmonize and improve work in the areas of prevention, diagnosis and treatment of malignant lymphomas.
F.17 Transfer of existing technologies, know-how, methods and procedures into practice
COBISS.SI-ID: 1704571