N1-0022 — Final report
1.
Proteomic approaches for identification of substrates of cysteine proteases

In this doctoral dissertation a detailed description of the novel Fast Proteomic Profiling of Protease Specificity (FPPS) approach is presented.

D.09 Tutoring for postgraduate students

COBISS.SI-ID: 274200576
2.
Cathepsin-binding compounds bound to a carrier and their diagnostic use

In this patent we described how cysteine cathepsins are suitable targets for targeted delivery of imaging agents and drugs to the inflammation site in disease, in particular cancer, and protected a delivery system based on targeting of cathepsin B at the inflammation site by a liposomal system conjugated to a small molecule cathepsin B inhibitor. The imaging agent, and possibly drug, are encapsulated in the lysosome.

F.32 International patent

COBISS.SI-ID: 29338663
3.
Organization of EMBO workshop Mitochondria, apoptosis and cancer

Organization of a prestigious EMBO workshop is a major achievement in the field and a major promotion of Slovenia. This workshop was organized on a topic of the project linking apoptosis and cancer, and was only the second EMBO workshop in history organized in Slovenia

B.01 Organiser of a scientific meeting

COBISS.SI-ID: 291672832
4.
Cysteine cathepsins as targets for noninvasive whole body imaging and targeted drug delivery

This lecture covered the topic of cysteine cathepsins as targets in drug delivery and diagnostics, presenting also the findings of the project.

B.03 Paper at an international scientific conference

COBISS.SI-ID: 30360871
5.
Role of cysteine cathepsins in extra- and intracellular signalization

In this PhD thesis identification and in vivo validation of membrane-anchored substrates of cathepsins was presented.

D.09 Tutoring for postgraduate students

COBISS.SI-ID: 280274432