In the scope of this applicable scientific publication, we have carried out activities with the aim to identify a new lipstatin-producing strain. Lipstatin is an inhibitor of pancreatic lipase of medical importance. Authors focused their work on isolation of new strain, potentialy producing less lipstatin-related impurities, which are biosynthesised due to promiscous nature of the enzymes involved in the provision of building blocks. A new strain, Streptomyces virginiae CBS 314.55 was isolated by dereplication screening approach based on the taxonomic criteria. Promiscuity of the selected enzymes from primary metabolism involved in the provision of building blocks for lipstatin biosynthesis was described in the patent application EP2141236. The work described in this research article describes isolation of new lipstatin-producing strain with different profile of impurities. Some of the methodological approaches in this work relates to the current work in the scope of the current project.
COBISS.SI-ID: 4372088