1.

First inter-laboratory comparison exercise for the determination of anticancer drugs in aqueous samples

The results of an inter-laboratory comparison exercise to determine cytostatic anticancer drug residues in surface water, hospital wastewater and wastewater treatment plant effluent are reported. Nine laboratories worldwide confirmed their participation in the exercise. The compounds selected included cyclophosphamide, ifosfamide, 5-fluorouracil, gemcitabine, etoposide, methotrexate and cisplatinum.

COBISS.SI-ID: 28748839

2.

Occurrence of cyclophosphamide and ifosfamide in aqueous environment and their removal by biological and abiotic wastewater treatment processes

Here we report the occurrence and removal efficiency of cyclophosphamide (CP) and ifosfamide (IF) by biological and abiotic treatments including advanced oxidation processes (AOPs).

COBISS.SI-ID: 28642343

3.

Assessment of toxicity and genotoxicity of low doses of 5-fluorouracil in zebrafish (Danio rerio) two-generation study

Residues of anti-neoplastic drugs are emerging pollutants in aquatic environments, where missing chronic ecotoxicity data present a critical knowledge gap. 5-fluorouracil was investigated in chronic two-generation toxicity study on zebrafish (Danio rerio) and genotoxic effects were detected at low for environmental exposure relevant concentrations.

COBISS.SI-ID: 3417935