Here we report the occurrence and removal efficiency of cyclophosphamide (CP) and ifosfamide (IF) by biological and abiotic treatments including advanced oxidation processes (AOPs).
COBISS.SI-ID: 28642343
Residues of anti-neoplastic drugs are emerging pollutants in aquatic environments, where missing chronic ecotoxicity data present a critical knowledge gap. 5-fluorouracil was investigated in chronic two-generation toxicity study on zebrafish (Danio rerio) and genotoxic effects were detected at low for environmental exposure relevant concentrations.
COBISS.SI-ID: 3417935
Acoustic cavitation is a known water treatment, whereas hydrodynamic cavitation (HC) has only recently been addressed. Firstly, a general overview of HC as water treatment is presented. In the second part we represent the outcomes of our work, where HC was assessed in terms of removal of selected pharmaceuticals, cyanobacteria, green microalgae, bacteria and viruses from water. We have shown that HC can manifest itself in various forms, each having its own distinctive mechanism. Since this was neglected in the past, it has led to poor performance of HC. We intend to show in our future work that a different type of HC (different removal mechanism) is required for successful removal of various pollutants. HC is not the method of choice for routine water cleaning at present. Regardless, our the recent results have shown its great potential as the optimization could lead to a low energy water treatment technique.
COBISS.SI-ID: 3649871
Fluorouracil is a fluorinated pyrimidine analogue important in the treatment of cancer whose fate in the environment is yet to be fully addressed. Due to its high polarity the compound requires challenging sample preparation and therefore we thoroughly investigated different solid phase extraction mechanisms (ion pair, ion exchange, reversed phase), sorbents and derivatisation agents to enable tracelevel analysis of fluorouracil. The achieved limits of quantification (LOQ) for waste and surface waters were 1.6 ng/L and 0.54 ng/L, respectively. The method was used to analyse samples of hospital, wastewater treatment plant influent and effluent and surface waters. Fluorouracil was quantified in four samples of oncological ward wastewaters and municipal wastewater treatment plant influents in concentrations from 4.7 ng/L to 92 ng/L. This work is also the first to study the environmental transformation of fluorouracil and its prodrug capecitabine. Their removal and transformation was simulated using a series of biodegradation and photodegradation experiments, where fluorouracil proved more degradable in comparison to capecitabine. Transformation of fluorouracil and capecitabine was studied by high resolution and tandem mass spectrometry. Overall, six transformation products for fluorouracil and ten for capecitabine are proposedÍž 13 of these are to our knowledge published for the first time.
COBISS.SI-ID: 26628903
Paper evaluates biological treatment, hydrodynamic cavitation and UV treatment as a method for wastewater treatment. In collaboration with Faculty of Mechanical Engineering and Faculty for Civil Engineering, University of Ljubljana we evaluated the efficiency of single processes as well as their sequences for removing micropollutants, e.g. pharmaceutical residues, from wastewaters. Ultrasonics Sonochemistry, ISSN 13
COBISS.SI-ID: 26582055