1.

Imaging cardiac stem cell transplantation using radionuclide labeling techniques

Stem cell therapy is emerging as a potential new therapy for patients with advanced heart failure. In recent years, advances in molecular imaging have allowed monitoring of stem cell homing and survival. In this review article, we describe the clinical application and future directions of stem cell imaging in advanced heart failure.

F.21 Development of new health/diagnostic methods/procedures

COBISS.SI-ID: 1267628

2.

The presence of electromechanical mismatch in nonischemic dilated cardiomyopathy is associated with ventricular repolarization instability

The electromechanical mismatch (EMM) and its relationship to ventricular repolarization in patients with nonischemic dilated cardiomyopathy (DCM) was analyzed. Conclusions: EMM is present in more then half of dilated cardiomyopathy patients, is associated with higher QT variability, and higher ventricular arrhythmia risk.

F.21 Development of new health/diagnostic methods/procedures

COBISS.SI-ID: 31857881

3.

Immunologic network and response to intramyocardial CD34(+) stem cell therapy in patients with dilated cardiomyopathy

Our objective was to determine whether baseline differences in circulating immunologic and nonimmunologic biomarkers may help to identify patients more likely to respond to intramyocardial injection of CD34+-based stem cell therapy. We identified 9 baseline factors that were associated with both stem cell response and stem cell retention. Among the baseline factors positively associated with both clinical response and stem cell retention were G-CSF, SDF-1, LIF, MCP-1, and MCP-3. Among baseline factors negatively associated with both clinical response and retention were IL-12p70, FASL, ICAM-1, and GGT.

F.22 Improvement to existing health/diagnostic methods/procedures

COBISS.SI-ID: 2448300

4.

Pre-transplant red cell distribution width predicts short term outcome after heart transplantation

Parameters associated with poor CD34(+) stem cell mobilization in advanced chronic heart failure (CHF) patients were investigated. Significant differences between poor and good mobilizers were found regarding NT-proBNP levels and red cell distribution width (RDW). Increased RDW was the only independent predictor of poor CD34(+) stem cell mobilization on multivariable analysis and may serve as a biomarker of poor stem cell mobilization in CHF patients.

F.22 Improvement to existing health/diagnostic methods/procedures

COBISS.SI-ID: 2506412

5.

Efficacy of CD34[sup]+ stem cell therapy in nonischemic dilated cardiomyopathy is absent in patients with diabetes but preserved in patients with insulin resistance

We evaluated the association of diabetes and insulin resistance (IR) with the response to cell therapy in patients with nonischemic dilated cardiomyopathy (DCM). Transendocardial CD34+ cell therapy appears to be ineffective in DCM patients with diabetes. IR was associated with improved CD34+ stem cell mobilization and a preserved clinical response to cell therapy.

F.22 Improvement to existing health/diagnostic methods/procedures

COBISS.SI-ID: 32541145