J3-5500 — Annual report 2013
1.
Surface-layer (S-layer) of human and animal Clostridium difficile strains and their behaviour in adherence to epithelial cells and intestinal colonization

In this study, we characterized the S-layer protein A (SlpA) of animal and human strains belonging to different PCR-ribotypes (PR) and compared the in vitro adherence and in vivo colonization properties of strains showing different SlpA variants. Adhesion assays indicate that C. difficile strains vary in their capacity to adhere to cells in culture and that adhesion seems to be independent of the SlpA variant. Colonization properties were assessed in vivo using a dixenic mouse model of colonization. One of the strains had advantage in colonizing the intestinal mice niche.

COBISS.SI-ID: 512343352
2.
Gut microbiota patterns associated with colonization of different clostridium difficile ribotypes

Publication includes advanced analysis approaches on C. difficile related data in which two researchers of actula project have previously collaborated (Rupnik, Džeroski).

COBISS.SI-ID: 16731158