Induction of the SOS response plays a significant role in pathogenesis of a wide spectrum of pathogens, including pathogenic Escherichia coli pathogenic strains, facultative intracellular pathogens that may replicate within macrophages, as well as among opportunists that may cause severe, even life-threatening infections.
F.02 Acquisition of new scientific knowledge
COBISS.SI-ID: 4121167The inducible DNA damage repair system, SOS regulates the synthesis of bacteriocins of E. coli designated colicins. The main regulator of the system, protien LexA, represses expression of colicin activity genes, in some instances in concert with protiens IscA and AsnC.
B.04 Guest lecture
COBISS.SI-ID: 3605327Description of the mechanisms of action of the various antibiotic types and problematics of antibiotic resistance
D.10 Educational activities
COBISS.SI-ID: 3687503The human gut harbors more than 1014 microbial cells that are designated as the gut microbiota. Due to interactions with the host, the gut microbiota plays and extremely important role in development and health. On the other hand, perturbations in the microbiota, dysbiosis are associated with metabolic and immune diseases including obesity and diabetes.
F.02 Acquisition of new scientific knowledge
COBISS.SI-ID: 3310415To gain insight into the responses of sensitive bacterial populations to colicin M in the natural environment and when applied as an antimicrobial agent we studied the response of an E. coli strain to ColM subinhibitory concentrations on a global gene expression scale using DNA microarrays and physiological tests. Transcriptomic analysis showed increase expressioin of envelope, osmotic and other stress responses including the two.component system creBC.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 773239