Backgrounds. Treatment of total edentulism with implant-supported overdenture is an established alternative to the conventional removable denture, especially in the case of poor anatomical conditions in the mandible. The aim of our study was to estimate the difference in satisfaction based on the quality oflife aspect in totally edentulous Slovenian patients treated with mandibular implant-supported overdentures or conventional removable dentures by using a standardized questionnaire. Methods. The study enrolled 50 patientstreated with mandibular implant-supported overdentures and 63 patientstreated with conventional removable dentures. This number also includes 8 patients with very po or anatomical conditions who were followed-upprospectively and asked to rate their satisfaction with the prostheses prior to and after treatment with implant-supported overdentures. The patients were asked to complete a custom questionnaire about their generalhealth and prosthetic treatment and the standardized Oral Health Impact Profile questionnaire, which assesses physical dysfunction as well as the social and psychological influence ofvarious dysfunctions and diseases of the stomatognathic system and their influence on general health. Results. Patients treated with implant-supported overdenture are generally more satisfied than those treated with conventional removable dentures (p ( 0.01), which is even more obvious in the prospectively assessed group of patients. Questions for assessing functionallimitations of the stomatognathic system andprosthetic appliances and physical pain in the stomatognathic system yielded statistically significant differences (p::; 0.05) between the two group s in ~ 50% of answers. In other group s of questions assessing psychosocial and general handicap, a statistically significant difference (p::; 0.05) was found in less than 50% of answers in a particular group of questions. (Abstract truncated at 2000 characters)
COBISS.SI-ID: 29424857
The aim of the present study was to investigate the effect of meloxicam and meloxicam with misoprostol on prostaglandin E2 (PGE2) and prostaglandin I2 (PGI2) serum concentration, as well as on gastrointestinal permeability. NSAIDs, such as meloxicam, have gastrointestinal side effects, which are due to prostaglandins depletion and topical damage. Seven adult beagle dogs were included in the study. Three different 20 days long treatments were carried out (placebo, meloxicam and meloxicam with misoprostol). The same seven dogs participated in all three treatments. On days 1 to 10 the dogs received placebo, meloxicam or meloxicam together with misoprostol PO. Dogs were than monitored from day 11 to 20. Samples for serum PGE2 and PGI2 concentration and plasma lactulose, mannitol and sucrose concentration determination were drawn on day 0, 2, 6, 11 and 20. Lactulose/mannitol (L/M) index was calculated. Treatment with meloxicam and meloxicam with misoprostol resulted in lower PGE2 and PGI2 serum concentrations in comparison to the placebo. L/M index and sucrose plasma concentration were increased in both groups in comparison to the placebo. According to the results of the study, meloxicam has altered gastrointestinal permeability and depleted prostaglandins production. Misoprostol was shown to be an effective preventing treatment.
COBISS.SI-ID: 3325050