J1-4131 — Annual report 2013
1.
Synthesis and physico-chemical characterization of novel coordination compounds with quinolones

Young researcher Jakob Kljun successfuly finished his Ph.D. study on isolation of ruthenium compounds with quinolones and their characterization. The supervisor of his work was professor I. Turel. It is worth to note that later Jakob Kljun was employed at the Faculty of Pharmacy (UL FFA) and successful cooperation is continuing.

D.09 Tutoring for postgraduate students

COBISS.SI-ID: 266499072
2.
National radio interview.

I was asked by journalist Štefan Kutoš to present my research work on metal complexes.

B.06 Other

COBISS.SI-ID: 36690949
3.
Speciation of Ru-based candidate chemotherapeutic drugs in human serum with 2D monolithic chromatography

Conjoint liquid chromatography (CLC) on monolithic convective interaction media (CIM) disks coupled on-line to UV and inductively coupled plasma mass spectrometry (ICP-MS) detectors was used in speciation analysis of Pt in human serum spiked with Pt-based chemotherapeutics. CIM Protein G and CIM DEAE disks were assembled together in a single housing forming a CLC monolithic column. Such a set-up allows rapid two-dimensional separation by affinity and ion-exchange (IE) modes to be carried out in a single chromatographic run. Separated Pt species were quantified by post-column isotope dilution—ICP-MS. The method developed may be reliably applied in preclinical and clinical studies of the kinetics of the interaction and distribution of different metallodrugs with proteins in blood serum.

B.03 Paper at an international scientific conference

COBISS.SI-ID: 27382311