J1-4121 — Final report
1.
Lysosomotropic compounds

In this lecture the latest results obtained with several lysosomotropic compounds, including LeuLeuOMe, siramesine and N-dodecyl imidazole, were presented. With the exception of LeuLeuOMe, which is the only true lysosomotropic detergent, all other compounds seem to trigger cell death through mitochondria.

B.04 Guest lecture

COBISS.SI-ID: 27208999
2.
Membership in Academia Europea (London)

Prof. Boris Turk was in 2013 elected for a member of one of the most renowned international academies, which is clearly a major recognition for both the researcher and Slovenia

E.02 International awards

3.
Guidelines for the use and interpretation of accays for monitoring autophagy

In this article, which includes as the coauthors all the important people working in the field of autophagy, a detailed critical overview ot the methods used in autophagy is given, together with the guidelines to results interpretation. It is therefore very important for us that the society considers us as important research group.

F.31 Development of standards

COBISS.SI-ID: 3840104
4.
The effect of siramesine on cell death pathway and comparison to other lysosomotropic reagents

In her doctoral dissertation Maruša Hafner Česen focused on understanding of the mechanism of action of several lysosomotropic compounds with major focus on siramesine. Although all of the compounds were found to trigger cell death, only LeuLeuOMe was found to act as a lysosomotropic detergent.

D.09 Tutoring for postgraduate students