DC-SIGN is a C-type lectin selectively expressed by certain types of DCs. We examined the role of DC-SIGN engagement limited to the stage of IL-4-guided differentiation of DCs from human peripheral blood monocytes. DCs indicated a tolerogenic potential by possessing a low, allostimulatory capacity and inducing naive, allogeneic CD4(+) T cells to produce low levels of IFN-?. Upon activation, IL-10 production was greatly increased by such DCs. Collectively, evidence is presented confirming a crucial role for DC-SIGN signaling in DC generation from monocytes
COBISS.SI-ID: 2985329
DC-SIGN is a lectin whose expression is restricted to the most potent antigen-presenting cells, the dendritic cells. In recent years, DC-SIGN has gained an increase in attention because of its involvement in multiple aspects of immune function. Besides being an adhesion molecule, it is also crucial in recognizing several endogenous and exogenous antigens. Additionally, the intracellular domain of DC-SIGN enables the activation of signal transduction pathways. In this article, we will discuss recent advances on a broad perspective concerning DC-SIGN structure, signalling and immune function.
COBISS.SI-ID: 2770545