1.

The expression of COX-2, hTERT, MDM2, LATS2 and S100A2 in different types of non-small cell lung cancer (NSCLC).

Using the real-time reverse transcription polymerase chain reaction (RT-PCR), we analysed the expression of the COX-2, hTERT, MDM2, LATS2 and S100A2 genes and researched the relationships between the tumour types and the differences in expression levels. The differences in the expression levels of the LATS2, S100A2, MDM2 and hTERT genes are significant in different types of NSCLC. Our study revealed differences in expression patterns, which may mimic the expression of the individual NSCLC type, and also new relationships in the expression levels for different NSCLC types.

COBISS.SI-ID: 25342937

2.

Oligonucleotide DNA Microarray Profiling of Lung Adenocarcinoma Revealed Significant Downregulation and Deletions of VIPR1.

The purpose of this study was to find novel genes involved in the development lung tumours. Using DNA microarrays, we identified 31 up-regulated and 8 down regulated genes in lung tumours. We described significant up regulation of the SPP1 gene, down regulation of VIPR1, and losses of the VIPR1 gene. Our findings complement a proposed VIPR1 tumour suppressor role in lung tumourigenesis, in which deletions in the 3p22 chromosome region are an important mechanism leading to loss of the VIPR1 gene.

COBISS.SI-ID: 26449625