Activation of DC-SIGN receptor with its specific ligands during differentiation of DCs from human monocytes, results in a formation of DCs with tolerogenic properties. After their activation with LPS, such DCs can't produce notable amounts of IL-12p70, but increase the production of IL-10. They also increase the expression of inhibitory molecules and are weak inducers of Th1 effector immune responses. During differentiation, the ligation of DC-SIGN down-regulates the STAT6 activation. After activation with LPS such DCs changed their ability to activate STAT1, STAT3, STAT6 and p38 MAPK.
COBISS.SI-ID: 2985329
In this review article we focused on the subject of recently discovered lectin receptor DC-SIGN, whose expression is selectively limited to DCs. DC-SIGN is a receptor with multiple functions, but potential implications of DC-SIGN in terms of immunomodulation of DCs are still remaining unanswered. In this article we have summarized and commented previous, as well as novel findings, concerning the immunomodulatory role of DC-SIGN as well as its function in recognition of pathogenic microorganisms.
COBISS.SI-ID: 2770545