We investigated the effect of ertapenem on carbapenem susceptibility of Pseudomonas aeruginosa. Antibiotic consumption was recorded monthly in defineddaily doses (DDD)/100 patient-days in the infectious diseases (ID), abdominal surgery (AS), and surgical intensive care units (SICU) of a teachinghospital from January 2005 to December 2008. Trends of decreased susceptibility of P. aeruginosa were observed in all three units. After the introduction of ertapenem, the number of P. aeruginosa isolates/ 1000 patients-days per month increased in AS and in SICU (p=0.05). The increase in carbapenem non-susceptible isolates/1000 patients-days in the same units was less significant (p=0.07 and p=0.054). Correlations between ertapenem and the carbapenem non-susceptibility for the lagtime of 1 to 6 months ahead gave no significant result. In the SICU, 30% of variability of carbapenem non-susceptibility could be predicted by the consumption of ertapenem. There is no evidence that ertapenem alters the P. aeruginosa susceptibility to carbapenems, but the relationship deserves further observation.
COBISS.SI-ID: 29066457
Objective: To investigate clinical and laboratory features of patients with Influenza A H1N1 virus infection hospitalized during 2009/2010 pandemic. Methods: Prospective observational study comparing clinical and laboratory characteristics of Influenza A H1N1 positive and negative patients with influenza-like illness (ILI). Results: From October 21, 2009 to February 14, 2010 196 ILI patients were admitted, of which 66 tested positive for Influenza A H1N1. The patients with H1N1 infection were younger (43 years vs. 65 years; P ( 0.01), more patients were pregnant (P ( 0.01), had allergies (P ( 0.05) or, asthma (P ( 0.01). H1N1 positive patients were more often febrile (91% vs. 72.9%; P ( 0.01) and had a higher prevalence of headache (31.8% vs. 18.5%; P ( 0.05). Lower values of C-reactive protein (88 pg/dl vs. 126 pg/dl; P ( 0.01), procalcitonine (0.42 microg/l vs. 3.98 microg/l; P ( 0.05), leukocyte count (7.4*10(9)/l vs. 11.7*10(9)/l; P ( 0.01) and higher values of troponin (0.162 micro/l vs. 0.146 microg/l; P ( 0.01) were found in H1N1 positive patients. More bacterial infections were found in H1N1 negative group(68.8% vs. 89.2%; P ( 0.05). Conclusion: In this study patients infected with Influenza A H1N1 differed from H1N1 negative ILI patients in several clinical and laboratory characteristics. The same was observed also by other investigators. The results of the study suggest some other specific features, such as a higher incidence of headache and higher values of troponin in Influenza A H1N1 infected patients.
COBISS.SI-ID: 28873945
Lactococcus garvieae is usually an animal pathogen. Only a few cases of infections in humans have been described. We describe a case of an elderly patient with prosthetic heart valves with a septicaemia without infective endocarditis, and with a favourable clinical course.
COBISS.SI-ID: 28874201