1.

RNA binding proteins in ALS/FTLD spectrum of diseases

Invited lecture at the meeting of Slovenian Biochemical Society

B.04 Guest lecture

COBISS.SI-ID: 35477765

2.

Familial mutations in the RNA binding gene FUS result in cellular mislocalisation of the protein

On this conference we reported mutations of FUS associated with amyotrophic lateral sclerosis (ALS). FUS is a nuclear protein, whose main known function is in metabolism of RNA (splicing and expression of mRNA, miRNA biogenesis, etc.). This finding suggests the increasing importance of RNA metabolism in neurodegenerative diseases, especially as TDP-43, another ALS associated protein has simillar characteristics.

B.03 Paper at an international scientific conference

COBISS.SI-ID: 23675687

3.

TDP-43 and FUS in amyotropic lateral sclerosis

Invited talk given at the Conference of Slovenian Neuroscience association. Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder characterized pathologically by ubiquitinated TAR DNA binding protein (TDP-43) inclusions. In 2008 we identified mutations in TDP-43 in sporadic and familial ALS cases. In 2009 we identified mutations in FUS also associate with ALS. Both proteins are involved in RNA processing and they indicate the increasing importance of understanding the RNA biology in neurodegenerative diseases.

B.04 Guest lecture

COBISS.SI-ID: 23059239

4.

Nuclear transport of TDP-43

Poster showing our achievements in understanding the nuclear transport of TDP-43. The poster was awarded the Sinapsa prise for the best poster in its category.

B.06 Other

COBISS.SI-ID: 25278503

5.

Expression of non-coding RNAS in human muscle tissue after bed rest and/or hypoxia

Talk on achievements and potential roles of noncoding RNA changes during prolonged simulation of microgravity environment.