1.

Controlled systemic release of interleukin-12 after gene electrotransfer to muscle for cancer gene therapy in combination with ionizing radiation

Gene therapy with cytokine coding DNA is effective tumor treatment. For systemic transgene release the musle is suitable transfection site, enabling the controlled release. The study has demosntrated that this approch has good antitumor effect on local tumor growth and metastases, also in combination with tumor or metastatses irradiation.

COBISS.SI-ID: 820091

2.

Local and systemic antitumor effect of intratumoral and peritumoral IL-12 electrogene therapy on murine sarcoma.

We evaluated the antitumor effect of IL-12 electrogene therapy on murine SA-1 sarcoma. The IL-12 plasmid was applied either intra- or peritumorally. Intratumoral EGT resulted in 90% complete response rate to treatment with 60% resistance to challenge with SA-1 tumor cells. Peritumoral EGT resulted in 16% complete response rate. Furthermore, significant growth delay of untreated tumors at a distant site was achieved. These data suggest that IL-12 EGT may be useful in the treatment of soft tissue sarcomas.

COBISS.SI-ID: 3131770