The behaviour of CoCrMo alloy has been studied in two simulated physiological solutions—NaCl and Hanks’ solutions—each containing the sodium salt of hyaluronic acid. The presence of hyaluronic acid in simulated Hanks’ physiological solution stimulates the formation of a calcium phosphate layer and enhances the activity of bone cells, opening up the possibility for tailoring the surface properties of CoCrMo alloy.
COBISS.SI-ID: 512333625
To improve the long-term performance of hip prostheses, alternative bearings with metal-on-metal and ceramic-on-ceramic couples have been introduced. When comparing two groups of similar patients undergoing total hip arthroplasty with the use of alternative bearings, ceramic-on-ceramic bearings had better survival than metal-on-metal. However, neither the ceramic nor the metal alternative provided improved midterm results when compared with the results of the conventional metal-on-polyethylene bearings.
COBISS.SI-ID: 26159143
Several cases of alumina ceramic hip replacement failures are reviewed fractographically. There is evidence that surgeons can damage the femoral head bore surface during surgery. Secondly, three of the failures described are of extended neck. Thirdly, while some failures show head bore surfaces which are clean apart from metallic witness marking, others show brown stains and white deposits suggesting poor conformal contact.
COBISS.SI-ID: 25895207
We compared the quality of debridement of chondral lesions performed by four arthroscopic and one open technique used prior to autologous chondrocyte implantation (ACI). Our study suggests that not all routine arthroscopic instruments are suitable for the preparation of a defect for ACI. We have shown that the preferred debridement technique is either open or arthroscopically-assisted manual curettage.
COBISS.SI-ID: 512119097
We employed genome-wide gene expression approach in order to discover novel genes involved in the pathogenesis of osteoporosis.One thousand six hundred six genes were found to be differentially expressed, indicating increased demand for protein synthesis and decreased cell proliferation rate in osteoblasts from osteoporotic tissue as compared to osteoblasts from non-osteoporotic tissue. In addition, differences in protein synthesis, cell proliferation rate and response to oxidative stress may also be involved in the pathogenesis of osteoporosis.
COBISS.SI-ID: 2678385