Microvesicles are present in all body fluids considered while the majority of MVs are created in vitro after the blood uptake due to the fragmentation of cells during the isolation. Heparin and beta 2 glycoprotein 1 mediate attractive interaction between membranes which presents a possible explanation for an anticoagulant, antimetastatic and antiinflammatory effect of heparin. A cholesterol and carbohydrate-rich meal causes a statistically significant increase of MVs in isolates from the blood of healthy subjects. In the isolates from the blood of patients with gastric cancer, concentration of MVs is increased with respect to the population of healthy subjects. Imatininb causes a transient increase of MV concentration in the blood isolates. The concentration of MVs in isolates is higher if the isolation is performed at lower temperatures,. Knowledge on MVs, their origin in vivo and in vitro and on the mechanisms which are connected to the physiological and patophysiological processes is still rudimentary. To perform population and clinical studies on large populations, the repeatability and accuracy of the method for the isolation of MVs should be improved.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 256629248A. Iglič is a co-editor of a series of publications which brings novel achievements in the field of phospholipid membranes.
C.01 Editorial board of a foreign/international collection of papers/book
COBISS.SI-ID: 8665428