J2-2197 — Annual report 2010
1.
Visualization of fragmented networks

We have developed a new network layout optimization technique which can incorporate additional information on relations between unconnected network components. It uses a two-step approach by first arranging the nodes within each of the components and then placing the components so that their proximity in the network corresponds to their relatedness. In the experimental study with on leukemia we demonstrate that FragViz can obtain network layouts which are more interpretable and hold additional information that could not be exposed using classical network layout optimization algorithms.

COBISS.SI-ID: 7964756
2.
Perspectives of the non-statin hypolipidemic agents

This review describes an important field of development of novel hypolipidemic drugs in humans where our group contributed extensively in recent years. Despite the fact that HMGCR inhibitors statins remain the most important hypolipidemics on the market, an increasing number of patients treated with statins increases as well the number of side effects and not-responders to the therapy. This review provides a detailed description of enzymes in cholesterol synthesis, focusing on the post-lanosterol part and strategies for new drug development.

COBISS.SI-ID: 26853081