J2-2197 — Annual report 2009
1.
Subgroup discovery from genetic and phenotypic data on wine yeast

We have developed a subgroup discovery technique that can be used to simultaneously mine two different sources of data on a single set of objects. The technique was used to find genetically (microsattelites) and phenotypically similar yeast strains. This is a typical demonstration of data integration as planned in our project.

COBISS.SI-ID: 7367764
2.
Transcriptional Activation of PPAR by Phenobarbital in the Absence of CAR and PXR

We studied the effect of phenobarbital in livers of wild type, CAR-/-, PXR-/- and CAR/PXR-/- knockout mice. In the absence of CAR and PXR, phenobarbital unexpectedly induced mRNAs of several nuclear receptors, including PPAR? and its target genes Cyp4a10 and Cyp4a14. We provide evidence that phenobarbital directly induces transcription of the PPAR? gene via its HNF-4? response element, and indirectly by lack of inhibitory crosstalk of AMPK, CAR and PXR with HNF-4?.

COBISS.SI-ID: 25879001