1.

The glypican 3-hosted murine Mir717 gene : sequence conservation, seed region polymorphisms and putative targets.

Mir717 (mmu-mir-717) was first reported in mouse, residing in the intron 3 of Glypican 3 (Gpc3) gene. Our present study revealed that the microRNA (miRNA) gene is conserved among 26 mammalian species. Additionally, A)G substitution was identified in the seed region of Mir717 among different mouse strains. We also compiled a total of 197 genes potentially targeted by Mir717, including nine genes that are associated with obesity and related phenotypes in mammals.

COBISS.SI-ID: 2780808

2.

Congenic and bioinformatics analyses resolved a major-effect Fob3b QTL on mouse Chr 15 into two closely linked loci.

We discovered that genomic region which was identified in previous experiments and exhibited effect of single locus consists of at least two closely linked loci Fob3b1 and Fob3b2. This result demonstrates the complexity of genetic architecture of quantitative traits and shows fractal nature of those loci, suggesting that such loci are composed of cumulative effects of the greater number of polymorphisms, which are closely linked.

COBISS.SI-ID: 2597000

3.

Defects in cholesterol synthesis genes in mouse and in humans : lessons for drug development and safer treatments.

The article offers a literature review in the field of transgenic models for cholesterol biosynthesis and critically analyzes plans and possible false interpretations for each individual animal model. The article will be useful for scientists, working in the field of biology of cholesterol biosynthesis,bur also for broader readership, not specialized in transgenesis.

COBISS.SI-ID: 2789256

4.

Revised classification of former genus Phoxinellus using nuclear DNA sequences.

Molecular data inferred from three nuclear DNA regions were used to re-examine the phylogenetic position and taxonomic status of former Phoxinellus taxa. Our results confirm a previous notion that the former genus Phoxinellus is not a monophyletic group but rather a grouping of independent lineages.

COBISS.SI-ID: 2740360

5.

Resolving taxonomic uncertainties using molecular systematics : Salmo dentex and the Balkan trout community.

The genetic structure of Salmo dentex and its phylogenetic relations to sympatric salmonids in the Neretva and Skadar River basins were evaluated using mitochondrial DNA (mtDNA) control region, eight microsatellites, and somatolactin (SL) gene. We hypothesize S. dentex to be a particular life history form of S. marmoratus in the Neretva basin and of S. trutta in the Skadar basin. These results clearly demonstrate that S. dentex does not represent a monophyletic lineage and should not be considered a distinct species.

COBISS.SI-ID: 2635656