The present innovation represents a platform comprising in vitro cell systems, methods and the standard compound for manipulation and/or monitoring of subcellular organelle traffic, important for the understanding of the fundamental cellular processes as well as for the applications in advanced approaches in medicine, biotechnology, pharmaceutical industry and other related fields. The innovation and novelty of the proposed patent application is the combination (platform) of approaches, consisting of the i) method for monitoring subcellular organelle dynamics to screen for biologically active substances (i.e. constituents of sera, cerebrospinal fluid and other biologically relevant small inorganic and organic substances and mixtures of these), ii) method for the determination of the quality of cells destined to be used in advanced medical therapies and iii) method for assaying and controlling the production of recombinant proteins within eukaryotic cells, in relation to organelle traffic. The invention offers the basis for the development and optimization of different pharmacologically relevant compounds for the treatment/modulation of pathological states, associated with the intercellular communication and hence with subcellular organelle traffic.
F.21 Development of new health/diagnostic methods/procedures
COBISS.SI-ID: 29542617