Dynamic optical microscopy was used to measure the size of degradation fragments of blood clots exposed to slow or fast tangential flow of plasma containing tissue-plasminogen activator. The size of clot fragments was larger and thrombolysis proceeded faster with fast tangential flow than with slow flow. This work proves that shear forces of flowing blood markedly contribute to biochemical thrombolysis
COBISS.SI-ID: 23815719
To date, venous thrombosis and arterial atherosclerotic disease were treated as two separated disease entities. However, our study demonstrated the existence of a tight association between venous thrombosis and arterial atherosclerotic disease. Thus, similar to the patients with atherosclerosis, patients with venous thrombosis exhibit an increased systemic inflammatory response and disturbances in the function of vascular wall , moreover, asymptomatic atherosclerotic changes in peripheral arteries are more common in patients with venous thrombosis compared to healthy people.
COBISS.SI-ID: 26612441
The study showed that in patients with idiopathic venous thrombosis vasodilatory capability of peripheral vessels is decreased and that it could be involved in the pathogenesis of venous thrombosis, especially in patients without risk factors.
COBISS.SI-ID: 27716569
We tested wheter noninvasive magnetic resonance imaging (MRI) can distinguish between retracted blood clots that are poorly susceptible to thrombolytic treatment and non-retracted blood clots that are more susceptible to thrombolytic treatment. A newer MRI method, apparent diffusion coefficient (ADC) mapping was found to better distinguish between retracted and nonretracted blood clots than the established method of T2 mapping. By ADC mapping we were able to depict retracted regions within blood clots that were poorly lysable by thrombolytic agents
COBISS.SI-ID: 23046183