1.

Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples

Paper describes a new nontoxic method for pathological protein deposits in brain samples of tauopathies. The method opens a possibility of nontoxic curcumin use for diagnosing these diseases in vivo and offers a basis for testing inhibitory effects of curcumin on the formation of pathological tau deposits in vivo.

F.21 Development of new health/diagnostic methods/procedures

COBISS.SI-ID: 26809305

2.

Donepezil inhibits diisopropylfluorophosphate-induced seizures and up-regulation of synaptotagmin 4 mRNA

Paper describes a possibility to employ Alzheimer disease medication to reduce organophosphate (e.g., in insecticides, nerve-agent warfare) intoxication effects.

F.21 Development of new health/diagnostic methods/procedures

COBISS.SI-ID: 27799257

3.

Use of 3D visualization of medical images for planning and intraoperative localization of superficial brain tumors: our experience

Together with neurosurgeons we introduced into clinical practice 3D Slicer-generated spacial reconstruction of MRI brain images. We used the visualization to plan the position of skin incision and bone trepanation. In all cases where this new approach was used the surgeons were able to remove the tumor in toto through a minimally invasive procedure. Our method yields a greater precision, lower invasiveness and reduced risk in brain surgery.

F.21 Development of new health/diagnostic methods/procedures

COBISS.SI-ID: 27474649

4.

Mitotic count, brain invasion, and location are independent predictors of recurrence-free survival in primary atypical and malignant meningiomas

Based on the WHO brain tumor classification, 10% of meningiomas belong into the higher maglignancy group. Although they often recur and locally invade brain parenchymum through infiltration, they are biologically heterogeneous. We studied 86 consecutive AMM patients who underwent surgery between 1990 and 2005 and looked at the histological, clinical and radiological characteristics which correlate with short survival time without recurrence. We found mitotic count, brain invasion and parasagital location to be independent predictors of the short recurrence-freesurvival.

F.21 Development of new health/diagnostic methods/procedures

COBISS.SI-ID: 512126777

5.

Exposure of rat pups to medical intensity ultrasound waves

We studied the medical ultrasound effects on gene expression in the central nervous system of rat fetuses exposed to medical ultrasound in utero. We employed an obstetric ultrasound device and a focused gene expression profiling on PCR nets. We found changes in cell adhesion and extracellular matrix, signal pathways, neurotrophic and neurotransmitter receptor protein genes. This report was selected and awarded as the best report at an international congress.

F.22 Improvement to existing health/diagnostic methods/procedures

COBISS.SI-ID: 26681305