Among 177 extended-spectrum ß-lactamase-producing Klebsiella pneumoniae isolates collected from 11 Slovenian hospitals in 2005 and 2006, 60 (34%), from eight hospitals, harbored genes for CTX-M enzymes, with blaCTX-M-15 detected by sequencing. These 60 isolates comprised 11 pulsed-field gel electrophoresis-defined strains, with several clusters of closely related isolates. Plasmids encoding CTX-M-15 enzyme were highly transmissible.
COBISS.SI-ID: 25391577
In this study, diagnostic accuracy of neutrophil and monocyte CD64 indexes (CD64in and CD64im) for sepsis in critically ill neonates and children was compared with that of lipopolysaccharide-binding protein (LBP), procalcitonin (PCT) and C-reactive protein (CRP). CD64in proved to be the best individual marker for bacterial sepsis in children, while in neonates the highest diagnostic accuracy at the time of suspected sepsis was achieved by LBP and 24 h later by CD64in.
COBISS.SI-ID: 26058457
Cathepsin X (CX), a cysteine protease, has been shown to regulate immune response by activating ß-2 integrin receptors. In this study the level of CX was determined in THP-1 monocyte cells primed with H. pylori (HP) antigens isolated from subjects suffering from gastritis, who had either eradicated or not the disease after the antibiotic therapy. We show the diversity of the innate immune response to HP antigens leading to either successful eradication of the infection or chronic inflammation, revealing CX location and activity as a regulator of the effectiveness of HP eradication.
COBISS.SI-ID: 2580849
Human papillomaviruses (HPVs) were detected in 69 (43.7%) of 158 and in 7 (4.5%) of 155 anogenital hairs obtained from 53 patients with genital warts (GWs) and from 53 age-matched healthy control subjects, respectively. For 91.9% of patients, the same HPV genotype was identified in GWs and hairs from at least 1 sampling site (pubic, scrotal, or perianal region). Having GWs was found to be strongly associatedwith the presence in anogenital hairs of the HPV genotype causing the GWs (range of odds ratios, 13.0-20.0).
COBISS.SI-ID: 25489625
In Europe, hantavirus disease or hemorrhagic fever with renal syndrome is an endemic zoonosis that affects tens of thousands of individuals each year. The causative agents are viruses of the genus Hantavirus, family Bunyaviridae, rodents and insectivores act as carriers. In all European countries there is a seroprevalence for hantaviruses in the general population but not all countries report cases. Here, we give an overview of the hantavirus situation in Europe.
COBISS.SI-ID: 26548185