Characterization of the functional effects of MMR mutations and polymorphisms is essential, not only for effective diagnosis of cancer predisposition, but also for choosing the appropriate chemotherapy, since it is known that MMR mutations can cause resistance to chemotherapeutic agents by insufficient induction of apoptosis. We assessed nine different MLH1 amino acid replacements with in vivo yeast-based approach.
COBISS.SI-ID: 4304666
The spread of metastases from a primary site through blood or lymphatic system resulting in the establishment of secondary tumors in distant locations is the main cause of death in cancer patients. The development of cells with metastatic potential requires the coordinated expression and function of genes in tumour cells and cells from surrounding tissue. Identification of molecules and signal pathways which contribute to metastasis is important for developing novel diagnostic and/or prognostic tests and for discovering novel therapeutic strategies to combat metastatic disease.
COBISS.SI-ID: 26743513
The aim of this study was to analyze genetic alterations of p53 gene in Slovenian gastric cancer patients and to compare them with clinicopathological parameters in order to assess the value of p53 as a prognostic factor.
COBISS.SI-ID: 3686426