Estimation of GFR is essential for the evaluation of patients with CKD. The Cockcroft-Gault and MDRD formulas are serum creatinine-based equations, and the most widely used tests for renal function. The present study compares own serum cystatin C-based equation and serum creatinine-based equations for 592 patients with CKD. Our results indicate that serum cystatin C-based equation is a reliable marker of GFR with a very high diagnostic accuracy and ability to predict patients with CKD and GFR under 60/ml/min/1.73 m2.
COBISS.SI-ID: 3015487
764 adult patients with CKD were enrolled. Their GFR was estimated using five equations based on creatinine, Cockcroft-Gault, MDRD and the Chronic Kidney Disease Epidemiology Collaboration equation and two cystatin C-based equations [simple cystatin C formula (GFR=100/cystatin C) and our own cystatin C formula (GFR=90.63 x cystatin C -1.192)]. The GFR was measured using CrEDTA clearance. Our results indicate that both serum cystatin C-based equations are reliable markers of GFR in patients with CKD reliable markers of GFR comparable with creatinine-based formulas.
COBISS.SI-ID: 3905599
592 adult patients with chronic kidney disease were enrolled. Their GFR was estimated using five equations based on serum cystatin C ((Larsson, Hoek, Grubb, simple cystatin C formula (GFR=100/cystatin C) and our own cystatin C formula (GFR=90.63 x cystatin C -1.192)). The GFR was measured using CrEDTA clearance. Our results indicate that all serum cystatin C-based equations, excluding the Larsson formula, are reliable markers of GFR in patients with CKD and for daily clinical practice the simplest formula (100/cystatin C) could be appropriate enough for GFR estimation.
COBISS.SI-ID: 3469375
Ocena glomerulne filtracije (GF) je pomembna za opredelitev ledvične funkcije bolnikov s kronično ledvično boleznijo (KLB). V pričujoči raziskavi so avtorji pri 252 bolnikih s KLB (GF < 90 mL/min/1.73 m2) primerjali ocene GF s pomočjo serumskega kreatinina, kreatininskega očistka po Cockcroft-Gaultovi formuli in serumskega cistatina C. Analiza korelacij in diagnostičnih zanesljivosti za različne označevalce GF je pri opazovani populaciji bolnikov pokazala superiornost serumskega cistatina C glede na serumski kreatinin.
COBISS.SI-ID: 2892607
317 adult Caucasians patients aged over 65 years were enrolled. We compare MDRD formula, CKD-EPI creatinine formula, CKD-EPI creatinine & cystatin formula and simple cystatin C formula (100/serum cystatin C) against 51CrEDTA clearance in the elderly. Our results indicate that simple cystatin C formula is reliable marker of GFR with high diagnostic accuracy and ability to predict GFR below and above 60 or 45 ml/min/1.73m2 in the elderly and is comparable to sophisticated creatinine formulas.
COBISS.SI-ID: 3751999