In this cross sectional case-control study 426 unrelated Slovene subjects (Caucasians) with type 2 diabetes mellitus were enrolled (283 patients with diabetic retinopathy and the control group of 143 subjects with type 2 diabetes without diabetic retinopathy. A significantly higher frequency of the VV genotype of the V16A polymorphism of the Mn-SOD was found in patients with diabetic retinopathy compared to those without diabetic retinopathy. The VV genotype of the V16A polymorphism of the Mn-SOD gene might be used as a genetic marker of diabetic retinopathy in Caucasians.
COBISS.SI-ID: 23663833
In the cross-sectional case-control study 206 patients with proliferative diabetic retinoapthy (PDR) and 143 patients without PDR were enrolled. Mean serum and vitreous levels of vascular endothelial growth factor (VEGF) were statistically significantly higher in PDR in comparison to the control group. Significantly higher serum and vitreous levels of VEGF were demonstrated in diabetics with the CC genotype. Despite the effect of the -634 C/G VEGF polymorphism on serum and vitreous levels of VEGF in PDR, it failed to contribute to the genetic susceptibility to PDR.
COBISS.SI-ID: 24565721