First, SPION nanoparticles were coated with 1-2 nm thick silica coating that contained significant pore fraction. Into the pores of silica coating we incorporated up to 30% of model drug (naproxen). After imersion into test solution the drug was readily dissolved. The prepared composites could be of potential interest for use in diagnostics.
COBISS.SI-ID: 4191258
Incorporation of drug into (nano)porous carriers is one of the important strategies towards better control of drug release. It has been reported that in certain cases the incorporated drug is dissolved even faster than if dissolved in a free form. Using rigorous mathematical modelling we were the first to explain such peculiar enhancement of release from nanopores.
COBISS.SI-ID: 4339738