1.

PANTER, Gabriela, KUŽNIK, Alenka, JERALA, Roman. Therapeutic applications of nucleic acids as ligands for toll-like receptors.

We described the application of nucleic acids that activate or inhibit Toll-like receptors TLR3, TLR9, and TLR7 with TLR8 based on results from our group and from the literature. Understanding of the molecular mechanism of activation is essential for the improved drug design.

COBISS.SI-ID: 4121114

2.

KUŽNIK, Alenka, PANTER, Gabriela, JERALA, Roman. Recognition of nucleic acids by toll-like receptors and development of immunomodulatory drugs.

Recent discoveries significantly improved our understanding of molecular mechanism of endosomal TLRs and their physiological role. Those include recognition of dsRNA through two nucleic acid binding sites of TLR3 ectodomain, activation of TLR9 by phosphodiester backbone of ssDNA, independent of the nucleotide sequence and phosphorothioate modified bonds, and the role of proteolysis in activation of TLR9. There is growing evidence that supports involvement of endosomal TLRs in a number of autoimmune diseases, suggesting a therapeutic potential of immunomodulatory endosomal TLR ligands.

COBISS.SI-ID: 4351258