1.

M. Oblak, T. Solmajer: Discovery of DNA gyrase B inhibitors, ZING Med. Chem. Conf. lead opt. and lead disc. Puerto Morelos, Mexico, Feb.1-4, 2009

In the conference in which the leading researchers of multinational pharma companies were taking part the project leader has presented the results of fragment based discovery of novel inhibitors of DNA gyrase and their potential use as antimicrobilas. The lecture has raised considerable interest of the conference delegates.

B.03 Paper at an international scientific conference

COBISS.SI-ID: 4138010

2.

Discovery of DNA gyrase inhibitors.

Our results on discovery of novel inhibitors of DNA gyrase using structure-based design and characterisation by biophysical methods were presented

B.03 Paper at an international scientific conference

COBISS.SI-ID: 2577777

3.

Structure-based discovery of novel bacterial gyrase inhibitors.

In the lecture we have revealed how the use of virtual screening based on cyclothialidine complex with DNA gyrase B enabled the discovery of novel analogs without lactone ring which renders the molecules pharmacokinetically unfavorable.

B.03 Paper at an international scientific conference

COBISS.SI-ID: 4174874

4.

Discovery of 2-amino-4-(2,4-dihydroxyphenyl)thiazoles as novel inhibitors of DNA gyrase B by structure-based virtual screening approach

Structure based virtual screening has resulted in a series of 2-amino-4-(2,4-dihydroxyphenyl)thiazoles which showed interesting activity in experimentally determined inhibitory activity against DNA gyrase B.

B.03 Paper at an international scientific conference

COBISS.SI-ID: 4486170

5.

DNA gyrase B : in silico discovery of 2.4-dihydroxyphenylthiazoles as novel atpase inhibitors

Structure based virtual screening of ATP binding site in the DNA gyrase B and the commercially available compounds database has resulted in a series of 2.4-dihydroxyphenylthiazoles as novel atp-ase inhibitors

B.03 Paper at an international scientific conference

COBISS.SI-ID: 4456986