We participated with poster at an international conference. We showed the results of the investigation for new endotoxin receptor MD-2 inhibitors. Potential inhibitors were selected among the compounds with a high affinity to the MD-2 hydrophobic binding pocket and with thiol-reactive group that would covalently bind to the -SH group of free cysteine inside the pocket and thus irreversibly inhibit LPS-dependent signaling pathway.
F.02 Acquisition of new scientific knowledge
COBISS.SI-ID: 4037914We participated at an international conference of pattern-recognition receptors in human disease. We presented the results of study of paclitaxel and docetaxel binding into the hydrophobic pocket on human endotoxin receptor MD-2. We showed that paclitaxel, antitumor agent, and its analogue docetaxel bind to MD-2 and overlap with the binding site for bacterial endotoxin LPS, and thereby inhibit activation in HEK293 cells.
F.02 Acquisition of new scientific knowledge
COBISS.SI-ID: 3765018