J4-9606 — Annual report 2008
1.
LEGIŠA, Matic. A gene for enhancing primary metabolism and increasing productivities and yields.

At the Conference “Science to Market” the use of modified gene for the synthesis of a shorter 6-phosphofructo-1-kinase fragment that was protected by a patent has been presented. The gene might be used for enhancing the productivity of specific bio-products by various commercial microorganisms.

B.04 Guest lecture

COBISS.SI-ID: 4039450
2.
ŠOLAR, Tina. Regulation of metabolism at the level of 6-phosphofructo-1-kinase in filamentous fungus Aspergillus niger.

PhD Thesis of T. Šolar deals with the role of 6-phosphofructo-1-kinase (PFK1) from A. niger. A posttranslational modification of PFK1 enzyme has been described that resulted in formation of a highly active, citrate inhibition resistant shorter fragment. The modified enzyme was found to be activated to a higher level by specific activators in respect to the native enzyme, which caused deregulated metabolic flux through glycolysis. In the second part of her thesis T. Šolar showed that glucosamine-6-phosphate deaminase competed with PFK1 enzyme for the same substrate fructose-6-phosphate.

D.09 Tutoring for postgraduate students

COBISS.SI-ID: 242061568