Base on the experiments with artificial membranes a hypothesis has been put forward on a possible anticoagulant effect of plasma proteins (Urbanija et al., Chem. Phys. Lipids, 150, 49-57 (2007)). In testing the hypothesis in vivo, a pilot study involving healthy individuals has been elaborated within the project. Results show a negative correlation between the number of microvesicles isolated from peripheral blood and the ability of plasma to mediate attractive interaction between membranes, which is in favor of the hypothesis.
COBISS.SI-ID: 23693785
We have put forward a theory based on the microscopic description of lipid molecules and statistical physical description of the system where it has been taken into account that the intrinsic shape of lipid molecules and their local interactions render them anisotropic with respect to the in-plane orientation and the corresponding single-particle energy. We found that the proposed model explains the stability of inverted hexagonal phase of this system and the transition between the lamellar and the inverted hexagonal phase upon the increase of the temperature of the system.
COBISS.SI-ID: 15026265