1.

Guidelines to study cysteine cathepsin activity using "labeling ABPs".

In this paper we showed evaluation and biological relevance of activity-based probes for cysteine cathepsins, which were developed within the FP6 CAMP consortium. As a model system we have used synovial fibroblasts stimulated by inflammatory cytokines.

B.03 Paper at an international scientific conference

COBISS.SI-ID: 22066727

2.

Expression levels of selected cysteine cathepsins and matrix metalloproteases in rheumatoid arthritis and osteoarthritis.

V tem prispevku smo kot prvi naredili primerjavo med aktivnostmi in nivojem izražanja različnih proteaz pri revmatoidnem artritisu (RA) in artrozi (OA). Tako smo pokazali, da so v vzorcih sinovialnih tekočin bolnikov z OA ali RA prisotne aktivne oblike katepsinov B in S ter da vzorci bonikov z RA v primerjavi z bolniki z OA vsebujejo bistveno več katepsina S, kar kaže na to, da so vnetni procesi bistveno pomembnejši za razvoj bolezni pri RA kot pri OA.

B.03 Paper at an international scientific conference

COBISS.SI-ID: 22065191