1.

In vivo assessment and evaluation of lung tissue changes from non-contact endoscopic reflectance spectroscopy for improving lung cancer detection

We present a method for lung cancer detection exploiting reflectance spectra measured in vivo during endoscopic imaging of the lung. The results demonstrated significant differences between the normal tissue/benign lesions and the malignant lesions in terms of tissue blood volume fraction, blood oxygen saturation, tissue scatterer volume fractions, and size distribution. The results also showed that the malignant lung lesions can be differentiated from normal tissue/benign lesions with both diagnostic sensitivity and specificity of better than 80%.

COBISS.SI-ID: 16965160

2.

Acquisition of fluorescence and reflectance spectra during routine bronhchoscopy examinations using the ClearVu Elite device, pilot study

Fluorescence flexible bronchoscopy (FFB) has proved to be very useful for detecting carcinoma in situ and pre-cancerous lesions of the lung that are generally occult to white light reflectance bronchoscopy (WLRB). The increased sensitivity has caused a significant decrease of specificity, resulting in a large number of false positive signals that lead to a significant number of unnecessary biopsies. We have developed and have been testing a special system ClearVu Elite. There were differences found which are sufficiently pronounced to warrant initiation of a large, multicenter study.

COBISS.SI-ID: 19347743

3.

Combining field imaging endoscopy with point analysis spectroscopy for improving early lung cancer detection

We propose to combine field imaging endoscopy with point spectral analysis for improving the overall diagnostic accuracy in clinical lung cancer detection. For this purpose, we developed an integrated endoscopy system that uses autofluorescence imaging and white light reflectance imaging to obtain high diagnostic sensitivity, while at the same time uses non-contact point reflectance/fluorescence spectroscopy to reduce false positive biopsies, thus, achieve high diagnostic specificity, better than 80%.

COBISS.SI-ID: 19163943

4.

DNA-based sputum cell image analysis for lung cancer in a clinical setting

To measure cell nuclei characteristics, previously reported to express probability for lung cancer, in subjects with different forms of pulmonary disease and those without disease. Sputum and buccal cell samples were obtained from 846 patients without pulmonary disease, with nonmalignant disease, COPD, asbestosis, lung cancer, stained for DNA, scanned by cytometer and scored. Results demonstrate that the DNA cellular characteristics on cytometry were more frequent among subjects with lung cancer but also among subjects with other pulmonary disease compared to subjects witbout pulmonary disease

COBISS.SI-ID: 18833822

5.

Chitotriosidase activity in sarcoidosis and some other pulmonary diseases

Bolniki zrazličnimi pljučnimi boleznimi imajo zvišane vrednosti več označevalcev vnetja. V tej raziskavi smo skušali oceniti, ali bi bila določitev chitotriosidase v serumu koristna pri diagnozi in zdravljenju pljučnih bolezni. Rezultati so pokazali, da je aktivnost chitotriosidase povečana pri kroničnih vnetjih pljuč kot so sarkoidoza, azbestoza, pljučni rak.

COBISS.SI-ID: 16043259