J7-9435 — Interim report
1.
Characterization of legumain degradome confirms narrow cleavage specificity

In this study we performed FPPS N-terminomics methodology, which confirmed narrow proteolytic specificity of legumain which cleaves its protein substrates exclusively after asparagine or aspartic acid.

COBISS.SI-ID: 32890663
2.
Cysteine cathepsins in extracellular matrix remodeling: Extracellular matrix degradation and beyond

In this review article we presented molecular mechanisms through which cysteine cathepsins affect physiological properties of extracellular matrix and their clinical implications.

COBISS.SI-ID: 31183911
3.
Protease specificity : towards in vivo imaging applications and biomarker discovery

In this review, published in a high impact journal, we presented the use of protese specificity in development of methodologies for in vivo monitoring of protease related physiological processes and biomarkers.

COBISS.SI-ID: 31598119