J3-8196 — Final report
1.
Extracellular vesicles as modulators of innate immune response

Invited lecture also on Mini-workshop on Extracellular Vesicles: From biophysical properties to therapeutic applications, 11. 4. 2019, Elettra Sincrotrone Trieste, Italy; Slovenian Physiological Society; Day of Physiology 2020, 2020, Ljubljana, Slovenia

B.04 Guest lecture

COBISS.SI-ID: 38811141
2.
Extracellular vesicles transfer of the myddosome as the proinflammatory signal from the Waldenström macroglobulinaemia lymphoma cells carrying MyD88L265P mutation

Short oral presentation. Also on the conferences Novel Concepts in Innate Immunity, 2017, Tubingen, Germany in 12. meeting of Slovenian Biochemical Society with inernational participation, 2017, Bled, Slovenia

B.06 Other

COBISS.SI-ID: 39552005
3.
Vaccines based on an antigen protein fused to a nanostructuring scaffold

The invention refers to a polypeptide comprising a genetically fused antigenic polypeptide domain with a scaffolding polypeptide domain that is configured to form a self-assembled nanoparticle, particularly a self-assembled soluble oligomeric nanoparticle, that comprises at least six copies of the antigenic domain. In another aspect, a DNA plasmid encoding protein antigen domains of the viral Spike protein of SARS-CoV-2 genetically fused to a scaffolding polypeptide domain is provided, which may be used as a vaccine against viral diseases such as against Covid-19.

F.32 International patent

COBISS.SI-ID: 43483395
4.
The role of extracellular vesicles and their synthetic analogues in the modulation of TLR4 activity

PI is a mentor to PhD students. Van Thai Ha finished his PhD in 2020

D.09 Tutoring for postgraduate students

COBISS.SI-ID: 56449027
5.
Promotion of science to lay public (an interview)

Members of the project are strongly involved in popularization of science among lay public. Paper published in Blood was presented in media: Delo, Dnevnik, Slovenske novice, portal RTVSLO.SI, Tromba.si. The members often present their scientific achievements in educational and science program on national TV and radio. In the case of high-impact achievements or awards they were also invited to present in prime-time news programs.

D.10 Educational activities

COBISS.SI-ID: 6338842